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Microsoft USB Natural Ergonomic Keyboard 4000 (Mouse and Keyboard Center) Driver

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💻 This driver download is available for Windows PCs.
At a Glance
DeviceMicrosoft USB Natural Ergonomic Keyboard 4000 (Mouse and Keyboard Center)
VendorMicrosoft
Supported OSWindows
VersionLatest
File Size—
UpdatedOct 29, 2026
SafetyScanned, malware-free
LicenseFree
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The Microsoft USB Natural Ergonomic Keyboard 4000 (Mouse and Keyboard Center) driver package helps Windows recognize the keyboard and enables supported customization options through Microsoft Mouse and Keyboard Center. While basic typing may work with Windows’ built-in USB keyboard support, the matching software lets you configure compatible shortcut keys and other keyboard-specific controls.

Key Features

  • Shortcut key customization: Assign supported programmable keys to frequently used commands, applications, or tasks.
  • Media and application controls: Configure compatible special keys for convenient access to playback controls and everyday functions.
  • Centralized keyboard settings: Use Microsoft Mouse and Keyboard Center to view and adjust the options available for your connected keyboard.
  • USB keyboard integration: Provides device-specific support alongside Windows’ standard keyboard functionality. Available settings can vary by software version and operating system.

How to Install

  1. Check your Windows version and system type. Before downloading, confirm whether your PC runs Windows 11, 10, 8, or 7, and check whether it requires a 32-bit or 64-bit package. Choose a release that explicitly lists compatibility with your operating system; one installer may not support every listed Windows version.
  1. Connect the keyboard. Plug the Microsoft USB Natural Ergonomic Keyboard 4000 directly into an available USB port. Allow Windows to finish detecting it, and confirm that basic typing works before installing additional software.
  1. Download the compatible package. Select the Microsoft driver or Mouse and Keyboard Center release intended for this keyboard and your version of Windows. Check the package details rather than assuming the newest release supports older systems.
  1. Run the installer. Open the downloaded setup file, approve the Windows permission prompt if it appears, and follow the on-screen instructions. Restart your computer if requested.
  1. Configure and test the keyboard. Open Microsoft Mouse and Keyboard Center and select the keyboard if prompted. Review the available key assignments, save your preferences, and test the shortcuts you use most often.

If the keyboard does not appear in the software, try another USB port and verify that the installed release supports both the device and your Windows version. A working typing connection does not necessarily mean every advanced control is supported by the selected software package.

Driver Details

DeviceMicrosoft USB Natural Ergonomic Keyboard 4000 (Mouse and Keyboard Center)
VendorMicrosoft
CategoryUSB
Supported OSWindows
PublishedOctober 28, 2026
UpdatedOctober 29, 2026
💻 This driver download is available for Windows PCs.